Multi-Omics for Health and Disease - 'Omics Production Centers (U01 Clinical Trial Not Allowed)
Department of Health and Human Services National Institutes of Health
Posted on:
Application Deadline:
Expired
Type
Research/project funding
Reference Number
RFA-HG-22-009
The goal of this Funding Opportunity Announcement (FOA) is to establish Omics Production Center(s) (OPC(s)) that will be part of a collaborative initiative to advance the application of multi-omic technologies to study health and disease in diverse populations. Together with the Disease Study Sites (RFA-HG-22-008) and the Data Analysis and Coordination Center (RFA-HG-22-010), the Omics Production Center(s) will leverage clinical conditions where multi-omic approaches are expected to be most informative to: 1) explore the use of multi-omics, integrated with phenotypic and environmental exposure data, including social determinants of health (SDOH), to detect and assess molecular profiles associated with healthy and disease states; 2) develop generalizable data harmonization, integration, and analysis methods, as well as best practices and standards for the optimal application of multi-omics; and 3) create a multi-dimensional dataset that is available to the research community. The OPC(s) will be primarily responsible for using high high-throughput molecular assays to produce omics data from the biosamples provided by the Disease Study Sites (DSS, RFA-HG-22-008) and contributing to consortium-wide protocol development, data analysis, methods development, and the production of the multi-dimensional dataset. While this program may provide some insights into disease etiology, its primary goal is to validate and enhance generalizable multi-omic approaches to identify meaningful biological changes related to health and disease.
Categories: Education, Health, Environment.
Categories: Education, Health, Environment.
United States