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Funding Opportunity RFA-OH-25-001 from the NIH Guide for Grants and Contracts. NIOSH supports exploratory and developmental research projects (R21) that address issues related to diagnostic or treatment uncertainty with respect to individuals receiving monitoring and/or treatment under subtitle C of the James Zadroga 9/11 Health and Compensation Act of 2010 (Public Law 111-347, as amended by Public Laws 114-113, 116-59, 117-328, and 118-31). The WTC Health Program intends to increase opportunities for research on new, innovative approaches, interventions, techniques, or methodologies to improve treatment and diagnostic effectiveness through intervention, as well as support program evaluation.