Adolescent Overdose Prevention and SUD Treatment Initiative (R34 - Clinical Trial Optional)

Funding Opportunity RFA-DA-25-031 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) encourages pilot work and preliminary research to support preparation for large-scale, rigorous trials that will guide the expansion of effective, non-stigmatizing overdose prevention, SUD treatment and recovery services for adolescents. These studies could include examining changes in risk behaviors associated with overdose (e.g., using alone, carrying/using Naloxone). Outcomes of interest include but are not limited to harm reduction, recovery, treatment retention and effectiveness, quality of care, patient-centered outcomes, and implementation factors. The goal of this NOFO is to develop interventions that address effective, non-stigmatizing overdose prevention, SUD treatment and recovery services for youth that are effective, practical, cost-effective, scalable, and sustainable.