Adolescent Overdose Prevention and SUD Treatment Initiative (R21 - Clinical Trial Not Allowed)

Funding Opportunity RFA-DA-25-030 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages exploratory and developmental research to better understand adolescent illicit fentanyl use and overdose patterns among youth at high risk for overdose. Research studies should identify targets for overdose prevention and substance use disorder (SUD) treatment and recovery. Research studies may use a variety of approaches (e.g., leveraging existing data sources, survey research, social network analysis, new methods development, feasibility research). Outcomes of interest include but are not limited to prevalence of overdose and reduction in substance use, particularly fentanyl use or use of drugs that are commonly laced with fentanyl; unintentional use/overdose, use/overdose by risk group, stigma, family and environmental risk and protective factors, treatment engagement, youth perceptions of substance use, and optimistic bias.