Limited Competition: Data Analysis and Sharing Center (DASC) for the MACS/WIHS Combined Cohort Study (MWCCS) (U01 Clinical Trials Not Allowed)

Funding Opportunity RFA-HL-26-010 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to renew the MACS/WIHS Combined Cohort Study of HIV in United States Adults (MWCCS) for a 7-year project period (2026-2033). Continuation of this epidemiological cohort study of middle-aged and older people living with HIV (PLWH), along with comparable individuals living without HIV (PLWOH) will enable the continued follow-up of a deeply phenotyped cohort of approximately 5,500 participants from across the United States. This initiative will utilize a populomics approach, i.e., examination of health determinants across multiple scales of influence (e.g. molecular, cellular, physiological, lifestyle/behavioral, household, neighborhood, environmental, cultural, and sociopolitical) using multi-disciplinary methods to investigate the web of influences impacting the health, quality of life, and survival of adults living with HIV. This NOFO seeks applications to fund a single Data Analysis and Sharing Center (DASC) for the MWCCS, with competition limited to institutions who were funded under RFA-HL-19-007.