This scholarship page was last updated on 03 June 2023. Some details may have changed since then. Please check the Department of Health and Human Services National Institutes of Health website or the Department of Health and Human Services National Institutes of Health page for current opportunities.

Precision Mental Health: Develop Tools to Inform Treatment Selection in Depression (UG3/UH3 Clinical Trial Optional)

Department of Health and Human Services National Institutes of Health

Tipo

Research/project funding

Posted on:

03 June 2023

Fecha de Cierre:

Expired

Reference Number

RFA-MH-24-120

The goal of this phased FOA (either R33/R61 or UG3/UH3) is to accelerate the development of sensitive biomarkers/tools to predict individual treatment-response between two or more existing treatments for depression. In phase 1 (up to 2 years) preliminary studies (e.g., retrospective secondary analyses of data from completed clinical trials and/or in nimble, fast-fail pilot studies) will de-risk the test technology demonstrating that there is enough signal for clinical utility (futility analyses, ROC curves, and/or effect size will be evaluated as go/no-go criteria). Phase 2 (up to 5 years) innovators will prospectively test the efficacy of the biomarker/tool in large-scale biomarker/tool-stratified clinical trials with the goal of beating standard-of-care decision-making (i.e., clinician/patient treatment assignment will be the CTRL group vs the test).
Categories: Health.

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