Using Neuromodulation to Characterize the Continuum of Pathophysiology Between Substance Use and Mental Health Disorders (R01 Clinical Trial Required)

Funding Opportunity RFA-DA-25-035 from the NIH Guide for Grants and Contracts. This NOFO seeks applications from the SUD and MHD research communities that coordinate efforts to characterize the effects of neuromodulation on brain circuits and behaviors relevant to both SUD and MHD. To accomplish this goal, studies would specify inclusion/exclusion criteria to capture variance in both SUD and MHD symptoms. Further, studies would include measures of engagement of circuit-level targets in response to neuromodulation and dimensional measures of cognition and behavior relevant to both SUD and MHD. This research approach uses circuit dynamics to understand neurobehavioral function and to develop ecologically valid and descriptive models of the shared and discrete dysfunction across these conditions.